ARCHAEA playing a key role in the microbiota of many higher organisms it seems quite natural to develop products aimed at being incorporated into food or nutritious supplements. Focusing on an oral formulation, we aim to optimize the microbiota towards better gut health. ARCHAEA is quite versatile for food industry applications, having heat-resistant properties, it remains bioactive when cooked or heat-treated. ARCHAEA probiotics are not eliminated by antibiotics, in contrast to other bacterial probiotics, thus emerging as a candidate to treat antibiotic associated diarrhea (AAD). Archaea co-exist in symbiosis with other components of the microbiome promoting diversification of the gut microflora.